Clinical Studies

Clinical Studies supporting the gamete and mucosal safety of the Therio-gel patented, isotonic formula:

  • Effect of an Isotonic Lubricant on Sperm Collection and Sperm Quality. Fertility & Sterility. 2013 In Press
  • Is Wetter Better? An Evaluation of Over-the-Counter Personal Lubricants for Safety and Anti-HIV-1 Activity. PLoS One. 2012;7(11):e48328. 
  • Quantitative Perceptual Differences Among Over-the-Counter Vaginal Products Using a Standardized Methodology. Contraception. 2011;84:184-193
  • Sperm Toxicity of "Nonspermicidal" Lubricant and Ultrasound Gels Used in Reproductive Medicine. Fertility & Sterility. 2011 Feb;95:835-836
  • Impact of Glycerol-free Versus Glycerol-containing Fertility Lubricants on Sperm Function: Including Ability to Fertilize and Support Embryo Development in an In Vitro Model. Fertility & Sterility. 2010 Sept(Suppl);94:209-210
  • Effect of an Isotonic Fertility Lubricant on Sperm Penetration into Bovine Cervical Mucus in Vitro. Fertility & Sterility. 2010 Sept(Suppl);94:210 
  • Preservation of Beluga (Delphinapterus leucas) Spermatozoa Using a Trehalose-based Cryodiluent and Directional Freezing Technology. Reproduction, Fertility & Development. 2010;22:653-663
  • Effect of Lubricants Developed for Fertility Markets on In Vitro Fertilization and Embryo Development. Journal of Andrology. 2009 Mar/Apr(Suppl):53
  • Equine Breeding Management and Artificial Insemination. J Samper © 2009
  • Comparative Effect of “Non-spermicidal” Lubricants on Stallion Sperm Function. Animal Reproduction Science. 2008 Sept;107:360
  • Mucosal Irritation Potential of Personal Lubricants Relates to Product Osmolality as Detected by the Slug Mucosal Irritation Assay. Sexually Transmitted Disease. 2008 May;35:512-516
  • Effect of Vaginal Lubricants on Sperm Motility and Chromatin Integrity: A Prospective Comparative Study. Fertility & Sterility. 2008 Feb;89:375–379
  • Semen Collection, Characterisation and Artificial Insemination in the Beluga (Delphinapterus leucas) Using Liquid-Stored Spermatozoa. Reproduction, Fertility & Development. 2008;20:770-783
  • The Effect of Different Lubricants on Longevity of Motility and Velocity of Stallion Spermatozoa. Theriogenology. August 2007:496
  • Animal Model Study of a New Patient Lubricant’s Affect on In Vitro Fertilization & Embryo Development. Journal of Andrology 2007;Mar/Apr(Suppl):28
  • The Effects of Vaginal Lubricants and Moisturizers on Computer Assisted Sperm Analysis (CASA) Parameters Associated with Cervical Mucus Penetration. American Society of Reproductive Medicine Annual Meeting, Philadelphia PA, October 2004
  • Effects of Personal Lubricants on In Vitro Fertilization and Embryo Development. American Society of Andrology Annual Meeting, Phoenix AZ, March 2003
  • Polysaccharides Containing Arabinose and Galactose Decrease Oxidative Damage to Sperm In Vitro. American Society of Andrology, Montreal Quebec, June 2001